Here’s Everything You Need to Scale Your Missouri Cannabis Business in 2025

Automated Metrc Integration 

Missouri’s state compliance system is Metrc, the leading state cannabis compliance system in the United States. There are many operators who rely on manual entry for tracking plants and products, however manual entry leaves a lot of room for risk. The compliance fees and fines significantly outweigh the cost of trustworthy compliance software. Competitive operators in Missouri are actively looking for cannabis software with an automated metrc integration to avoid manual entry errors. The leading cannabis ERP systems, like 365 Cannabis, are designed with compliance guardrails to ensure users stay within regulations at every step, something we pride ourselves on.  

Real-Time Inventory Control 

As a company grows, so do their assets and that includes every seed, every gram, every gummy. Having instant access to all products across cultivation, manufacturing, and retail is a non-negotiable for the leading Missouri cannabis operators. Real-time inventory control gives operators instant visibility into every SKU, eliminating blind spots and costly write-offs. The right cannabis software will track take account of everything within the supply chain and production schedule and be able to deliver Available-to-Purchase (ATP) data for sales (and here’s why that’s important).  

Integrated Cannabis-Focused Financial Tools 

Missouri’s cannabis community is booming and that means more money to manage for operators. Many businesses, cannabis or not, use QuickBooks. That’s a fair tool for some businesses, but it’s not designed or optimized at all for cannabis operators. Cannabis has unique challenges as a federally illegal, state legal, Schedule I substance subject to 280E. Outside of the QuickBooks limitations, due to cannabis being federally illegal, they do reserve the right to not support any cannabis enterprises, even fully legal and licensed ones. We’ve seen reported issues with QuickBooks as early as 2015 of entire financial recording software locked overnight. While QuickBooks does often turn a blind eye, they overall do not serve the needs of the cannabis community. ERP platforms have financial systems built into place that serve two functions- eliminating the need for third party financials like QuickBooks and integrating all efforts to ensure financial data is accurate. The 365 Cannabis financial module for example pulls financial data in from all sales, all purchases, all invoices, everywhere that touches the business to ensure every penny is accounted for. Native financial functions reduce the opportunity for human error and ensure every spend and every sale is accounted for.  

Data and Analytics for Decision Making  

Missouri’s cannabis market is still relatively young, which means consumer behavior is evolving quickly. Operators who rely only on historic sales data risk missing major shifts in category demand. Advanced analytics provide real-time visibility into product performance, costs, and margins, helping operators pivot quickly and stay ahead of competitors. Dashboards powered by tools like Microsoft’s Power BI allow businesses to identify growth categories, spot inefficiencies, and make data-driven decisions with confidence. In a fast-moving market, analytics are the difference between reacting to trends and leading them. 

Missouri cannabis operators are competing in one of the most dynamic markets in the country. Success in Missouri’s cannabis market demands excellence in compliance, product visibility, accuracy, finance, and control across the entire business. ERP built for cannabis, like 365 Cannabis, combines compliance, inventory, financials, and analytics into one platform designed for growth. 

If you’re ready to scale your Missouri cannabis operation, schedule a demo with 365 Cannabis and see how ERP can help you lead the market. 

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Because cannabis is a regulated product with strict expiration dates, operators must not only produce efficiently but also turn product quickly. The reality is that many overproduce which forces them to slash prices just to get product onto shelves. This cycle of oversupply and discounting has accelerated falling wholesale prices across the U.S. According to Cannabis Benchmarks, the weighted average price for a pound of cannabis dropped from $1,328 in August 2019 to just $1,093 in August 2025—a 17.7% decrease—while inflation rose by 26.36% in the same period.  

With rising costs of living and operating facing off with a race to the bottom, cannabis operators need smarter strategies to protect margins and stay competitive. 

Spoilers: we got your back on this but keep reading. 

How Can Cannabis Operators Control Their Sales Inventory?  

A major factor in the race to the bottom is discounting product pricing. Common reasons for discounting products are upcoming expiration dates and having too much product on hand and needing to make space. A solution that we have seen success with is Available to Purchase (ATP) in cannabis software.  

What is ATP in Cannabis?  

ATP is a live tool in cannabis inventory management software that delivers data to operators on how much cannabis can be legally and operationally committed to a sale. Basic inventory counts will only show how much finished product is ready to sell at that moment- just what’s on hand. An APT program is a comprehensive look at what you have on hand, what you have allocated to customer orders, what’s quarantined, what’s in the production cycle, and what’s pending testing. Where basic inventory reports give a surface-level snapshot, ATP provides a comprehensive, real-time picture of what’s actually sellable. 

How does ATP Help Cannabis Operators? 

ATP capabilities for cannabis management extend past sales availability; it can also be a compliance safeguard. The accurate numbers inclusive of products in testing or to be finished soon deliver accurate inventory across the board. This ensures alignment with the state compliance system and avoids unnecessary compliance penalties. Many ATP solutions also offer FIFO capabilities to ensure, true to form, product is sold on a first in, first out basis.  

ATP also prevents accidental oversell situations that may be costly and labor inducive to fix. Aside from oversells, there may be fees or penalties within state compliance systems for inaccurate product numbers. The ATP tool becomes a single source of truth for cannabis sales commitments and streamlines operations for your sales team.  

When paired with a cannabis ERP system that includes sales projection reporting, ATP gives operators the insights they need to forecast demand, control output, and maintain profitability.  

How Can Cannabis Operators Implement ATP Today? 

The fastest way to bring ATP into your cannabis operation is by using a cannabis ERP system designed for compliance and inventory management. With 365 Cannabis, ATP is powered by SellStack and can be built directly into cultivation, manufacturing, distribution, and retail workflows. That means operators can see, in real time, exactly what inventory is legally and operationally available to sell, without worrying about overselling, compliance discrepancies, or wasted product. 

By combining ATP with 365 Cannabis’ sales forecasting, costing, and compliance integrations, operators can finally take control of their inventory, protect profit margins, and stay competitive, even in an oversupplied market. 

To see the solution in action, schedule a demo with 365 Cannabis and discover how ATP can give your business the confidence to promise only what you can deliver. 

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This is not to say cannabis manufacturing does not come without its challenges. Legislation varies from state-to-state. The types of products being made – from edibles, to infused beverages, to cosmetics, and supplements – are tightly regulated. There are rapidly changing consumer preferences to consider, and of course – supply chain disruptions.

How can your cannabis manufacturing business navigate these complexities? Material Requirements Planning (MRP) software is a good place to start.

MRP System vs ERP System

MRP is a system designed to help manufacturers better manage their production, from material requirements planning, to inventory management, to waste reduction, and delivery. Simply put, it helps cannabis manufacturers better understand their operations so they can optimize their supply chain.

If you think it sounds similar to an ERP system, you’re not far off. In a way, MRP can best be described as a component of an ERP. It offers much of the same functionality as an ERP, while lacking the accounting and finance aspects you would expect from a true ERP system.

Benefits of Cannabis MRP

Why do manufacturers need a cannabis manufacturing software? You have likely relied on a seed-to-sale system to track your products throughout their lifecycle. However, as you look to scale your operation, you may find traditional seed-to-sale software to be limited in its features and functionality. This is where an MRP system can benefit your business.

Inventory management

Inventory makes up a significant portion of your operation’s expenses. It must be managed properly for you to remain profitable. With the help of cannabis MRP software, cannabis manufacturers can effectively monitor a wide range of products across various locations, providing you complete visibility into your manufacturing production.

Demand forecasting

The ability to forecast and plan for materials is a key component of successful supply chain management. It requires the review of critical data while also looking at a number of outside factors including current market trends and seasonal swings in consumer demands. Cannabis MRP software can help you keep this data organized and easy to access.

Waste Reduction

Cannabis MRP software allows operators to prioritize lean manufacturing – limiting overproduction, delays and underutilized materials – significantly reducing waste.

Cannabis MRP Software Built to Scale

Cannabis manufacturing can be complex. Cannabis MRP software allows you to manage all the moving parts of your business, remain flexible when challenges arise, and adapt to changing consumer demands. Request a demo of 365 Cannabis today!

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With growing competition and heavy regulations, cannabis cultivators, manufacturers, distributors, and retailers have been forced to evolve or perish. Most have faced or are aware of the challenges and trade-offs that affect their increasingly complex and competitive supply chains.

The easiest and most valuable way a cannabis business can increase profitability is with an optimized supply chain. The supply chain should stay lean, manage costs, and, most critically, respond instantaneously to fluctuations in demand.

While there is no single playbook to ensure success in the rapidly expanding and ever-changing industry of cannabis, here are five ways to optimize your cannabis supply chain.

5 Tips to Improve Your Cannabis Supply Chain

Process Mapping

Understanding how your business operates is the only way to critically evaluate your processes. The best way to audit your supply chain is to have established process maps in the first place.

If a new employee walked into the office today and they had to do a task with no formal instruction, just documentation, could they complete it?

Keeping your own updated documentation that includes your companies’ best practices and operating procedures ensures that information is not forgotten. Additionally, information is accessible to all employees.

Even more, process maps allow you to analyze efficiencies and make necessary changes as your business expands.

Focus on Strengths

Many cannabis businesses spread themselves thin by trying to do too many things. Or, they take on business-critical compliance and financial activities on their own.

Most often, outsourcing business-critical tasks to specialized third-party providers produces a better value in the long term.

If you have a team of master cultivators with extensive strain knowledge, why devalue that asset by stretching their bandwidth into balancing books or loading distribution trucks?

Focusing on your organization and team member’s core competencies will help you grow your business.

Build a Responsive Supply Chain

Utilize source data from your inventory management system, POS, as well as industry information to identify trends and demand changes to enable your supply chain to respond rather than react.

This is critical to increase sales, reposition inventory, maximize customer/vendor satisfaction. Historical data and emerging trends will greatly help forecasting/planning to build a responsive supply chain.

Regularly Audit Your Business

It is business-critical to establish regular reviews to ensure efficiency and alleviate risk.

You should constantly be reviewing procedures and policies to ensure compliance, efficiency, and currency.

This will help avoid process bottlenecks or bloats and help streamline operations while mitigating the risk of theft, fraud, and non-compliance.

Upgrade to a Cannabis ERP

The idea of upgrading to an ERP spook some cannabis businesses. Nonetheless, the overwhelming benefits to profits and efficiencies offset the possible disruption and costs.

A true cannabis-specific ERP houses all your core business operations in a single solution. This allows your business to extensively reduce or eliminate manual processes, increase efficiencies, focus on growth, and ultimately optimize your supply chain.

The cannabis supply chain has become an increasingly complex ecosystem of people, processes, and technologies. Luckily, ERP software has been designed to fit the unique needs of the industry to bring everything together in a single, centralized system. 

365 Cannabis delivers a vertically integrated ERP solution that is 100% dedicated to the cannabis industry. Request a demo to see how you can optimize your cannabis supply chain today!

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